New

Research Fellow In Cilia Biology, Cardiac Development and Zebrafish Genetics at the MGH Cardiovascular Research Center's Yuan Lab

Mass General Physicians Organization
United States, Massachusetts, Boston
185 Cambridge Street (Show on map)
Aug 03, 2025
The laboratory of Dr. Shiaulou Yuan at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) is seeking highly motivated candidates for a full-time postdoctoral research fellow position. We are a multidisciplinary group of biologists, biophysicists, and microscopists who aim to understand how fluid flows and biophysical forces shape the developing heart and how these mechanisms underlie cardiac disease pathogenesis when gone awry. Specifically, we seek to illuminate how the cilium, a hair-like structure found on most cells in the human body, acts as an "antenna" to sense and translate extracellular signals into molecular processes that sculpt the early heart (Djenoune, Mahamdeh et al., Science, 2023). The penultimate goal of our research is to advance our understanding of cardiac development and diseases by combining state-of-the-art approaches from developmental biology, cell biology, genetics, biophysics, and advanced microscopy in zebrafish animal models and human stem cells. This position offers excellent opportunities to work in a highly collaborative and multi-disciplinary biomedical atmosphere, interact with distinguished scientists, physicians and physician-scientists at MGH-Harvard, and become a valued member of a collegial and growing research team. As a member of Harvard University, Massachusetts General Hospital, Mass General Brigham, and the Boston scientific community, the candidate will be immersed in a rich environment for zebrafish genetics, cardiovascular biology, cilia signaling, molecular biology, and imaging technologies. REQUIRED SKILLS AND EXPERIENCE The ideal candidate will have: a strong background working with zebrafish a PhD, MD, MD/PhD or equivalent doctoral degree in a relevant field prior training in zebrafish husbandry and colony management, embryo micro-injection, embryo micro-dissection, confocal or light sheet microscopy, live cell imaging, quantitative image analysis, immunofluorescence, in situ hybridization, molecular cloning, CRISPR-Cas9 gene editing, recombinant protein, and/or human stem cell culture techniques a passion for developmental biology, cell biology, cardiovascular biology, and microscopy the ability to work independently and also as part of a team excellent written and verbal communication skills a strong work ethic and superb attention to details exceptional technical and experimental skills. experience training and supervising junior scientists, technicians and/or students Interested candidates should send a CV, a cover letter, and contact information for three references to Dr. Shiaulou Yuan (shiaulou.yuan@mgh.harvard.edu). Find out more about our lab's research:https://yuan.mgh.harvard.edu Review of applications will begin immediately and continue until the position is filled. EEO Statement Massachusetts General Hospital is an Equal Opportunity Employer.By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged. Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.